October 19, 2021
Presentations Focus on Modeling Mass Transfer to Aid the Product Scale-Up Process
The team from M-Star Simulations, LLC, will join major pharmaceutical partners at the 2021 AIChE Annual Meeting, being held Nov 7-11 (in Boston) and Nov. 15-19 (virtual), to present advances in computational fluid dynamics (CFD), which are helping model mass transfer and aid in the product scale-up process. M-Star’s leadership will be involved with eight presentations with partners that include Pfizer, Bristol Myers Squibb, Abbvie and AstraZeneca.
M-Star Simulations’ M-Star CFD software handles fluid dynamic simulations with millions of individually tracked bubbles, allowing biopharma companies to model complex bioreactor physics problems – including mass transfer and multiphase fluid flow – accurately and in minutes. M-Star CFD supported the rapid development and delivery of the Pfizer COVID-19 vaccine.
AIChE is the world’s leading organization for chemical engineering professionals, with more than 60,000 members from more than 110 countries. The presentations at AIChE’s Annual Meeting that include members of M-Star’s team are:
1. Predicting the Diameters of Droplets Produced in Turbulent Liquid-Liquid Dispersion
- 8 a.m. to 8:24 a.m. on November 8. In-person: Room 101, John B. Hynes Veterans Memorial Convention Center.
- Presenters: Francesco Ricci, Boehringer-Ingelheim Pharm. Inc.; John Thomas, Brian DeVincentis and Johannes Wutz, M-Star Simulations
2. A Mechanistic Approach for Predicting Mass Transfer in Bioreactors
- 8:24-8:48 a.m. on November 8. In-person: Room 101, John B. Hynes Veterans Memorial Convention Center.
- Presenters: Helen Hua, Bristol Myers Squibb (BMS); Grace Yao, BMS; John Thomas, Brian DeVincentis and Johannes Wutz, M-Star Simulations; Kathryn L. Aron, BMS; Michael Borys, BMS; Girish Pendse, BMS.
3. Fluid-Particle Coupling Across Relative Length Scales
- 3:55-4:20 p.m. on November 15. Virtual.
- Presenters: Brian DeVincentis and John Thomas, M-Star Simulations
4. A Mechanistic Approach to Predicting Oxygen Mass Transfer in Bioreactors
- 4:45-5:10 p.m. on November 15. Virtual.
- Presenters: Hooman Yadollahi Farsani, Pfizer; Pouria Motevalian, Pfizer; John Thomas and Johannes Wutz, M-Star Simulations
5. CFD Analysis of Sparger Design and Bubble Formation, Breakup, and Coalescence
- 8:50-9:15 a.m. on November 16. Virtual.
- Presenters: Christopher Tyler, Cargill, Inc.; John Thomas and Brian DeVincentis, M-Star Simulations
6. Modeling Gas-Liquid Mass Transfer Using a Discrete Bubble Method: An Application to Bioreactors
- 1-1:30 p.m. on November 16. Virtual.
- Presenters: John Thomas, M-Star Simulations; Lei Cao, Abbvie; Anisur Rahman, Abbvie; Ying Wang, Abbvie; Brian DeVincentis, M-Star Simulations
7. CFD Modeling of Bioreactors: Applying Euler-Lagrange LES Technique to Investigate Effect of Pressure and Sparge Air Flow on Dissolved CO2 Profiles in a Fermentation Process
- 1:30-2 p.m. on November 16. Virtual.
- Presenters: Navraj Hanspal, Corteva Agriscience; John Thomas, M-Star Simulations; Dale Brown, Corteva Agriscience
8. Oxygen Transfer in Bioreactors with High Cell Densities
- 2:30-3 p.m. on November 16. Virtual.
- Presenters: Nicholas Bernhard Guros, AstraZeneca; John Thomas, M-Star Simulations
“The number of major companies presenting with M-Star at AIChE proves how valuable M-Star CFD is to the scale-up process for their new drugs and products,” says John Thomas, Ph.D., President, M-Star Simulations. “Many of our partner pharma companies are competitors, but they called on us to help them bring their vaccines and other drugs to market faster. They trust M-Star CFD software to quickly perform calculations with predictive fidelity that rivals physical experiment.”
About M-Star Simulations, LLC
M-Star Simulations, LLC, is a software company focused on the development of computational tools for modeling momentum, energy and mass transport within engineering and biological systems. By pairing modern algorithms with graphical processing card (GPU) architectures, this software enables users to quickly perform calculations with predictive fidelity that rivals physical experiment. These outcomes are achieved using a simple graphical interface that requires minimal user specification and setup times. Founded in Maryland in 2014, M-Star Simulations has grown to include commercial, government and academic users across North America, South America, Europe and Asia.