Model Mass Transfer, Multiphase Fluid Flow & More in Bioreactors

Most biologic processes are developed in lab-scale tabletop bioreactors with small operating volumes. M-Star CFD helps you scale up processes from lab-scale to production-scale build with greater speed and fidelity than ever before.

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CFD Modeling Capabilities for Bioreactors

M-Star CFD was built to handle simulations with millions of grid points and millions of individually tracked bubbles. This allows you to model complex bioreactor physics problems—including mass transfer, multiphase fluid flow, and more—accurately and in minutes.

  • Gas Hold-Up​
  • Oxygen and CO2 Transfer​
  • Reactions
  • Bubble Break-Up Coalescence​

Mixing Bioreactors with Bottom Mounted Impellers

Learn how to use M-Star CFD ​to predict the single fluid and multi-fluid mixing behavior of bioreactors across a variety of scales, fluid volumes, and impeller speeds.

"A mechanistic approach for predicting mass transfer in bioreactors"​

Read how M-Star worked with Bristol-Myers Squibb to develop and validate physics-based models for predicting mass transfer in sparged bioreactors at multiple scales.

"Modeling mass transfer in stirred microbioreactors"​

Pfizer works with M-Star to present a mechanistic in-silico approach for predicting mixing and mass transfer in a two-phase stirred tank bioreactor.

Real-time CFD-Based Bioreactor Models with Integrated Process Control

M-Star President John Thomas highlights the transformative role of digital twins in reactor modeling, emphasizing a physics-based modeling approach over traditional methods.

Get Started with M-Star

Contact us to speak to an M-Star and CFD expert and get a customized demonstration and free trial.